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We might expect that even broader variety of resistance mechanisms would be revealed were it to be used in clinical settings

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p53 tumour-suppressor caution Because FOXO4-DRI intervenes in the p53 pathway, which is critical for tumour suppression, there is theoretical concern that interfering with p53 dynamics might carry oncogenic risk

Is the improvement in the Box Maze specific to hippocampal neurogenesis, or simply an overall reduction in age-related anxiety