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2013;8(9):e74014

[11] This may be due to a corresponding genetic predisposition to sequestering ferritin in the liver or due to an increased sensitivity to ethanol ingestion [11, 12]

doi: 10.3389/fbioe.2021.629270 241 KarageorgiouVKaplanD

In particular, the cystine/glutamate antiporter (System X c ), glutathione peroxidase 4 (GPX4) and glutathione (GSH) (System X c /GSH/GPX4 axis) plays a key role in preventing lipid peroxidation-mediated ferroptosis, because of which could be inhibited by blocking System X c /GSH/GPX4 axis

In addition, the anti-RA mechanism of ginsenoside Rg1 may be related to its anti-inflammatory effect by up-regulating peroxisome proliferators activated receptor- (PPAR-) and then inhibiting the NF-B signaling pathway (131)