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Furthermore, MD-based mutagenesis analysis revealed that a change in one of the key binding pocket amino acids (D174E) destabilizes the binding of TML to SLC25A45, reinforcing the high specificity of SLC25A45 to TML ( Fig

Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: Role of caspases, ROS, and JNK

Interestingly, the medications that may be the most effective at achieving the desired outcome can be the ones that are more likely to cause adverse effects

Although the BBB excludes many drugs, brain capillary endothelial cells express transporters and receptors that selectively import essential nutrients (e.g., insulin receptor, transferrin receptor, glucose transporter-1) [51]

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