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Following decapitation, brain tissues were immediately extracted and flash-frozen in liquid nitrogen

The potential target genes of a specific miRNA were identified using three common computation programs that are proved to predict the miRNA targets with better accuracy based on proteomic data [38]: miRDB ( [46, 47]), Diana microT v3.0 ( [48, 49]), and TargetScan 5.2 for mouse Only the gene which was identified as a candidate of a specific miRNA by at least two programs was classified as the candidate target gene