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When six volunteers inhaled 0.1 ml amyl nitrite 10 times for 20 seconds once per min, the median concentration of methaemoglobin was 3.45%, with a maximum of 6% and a minimum of 1.4%

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10.1038/S41392-020-00312-6 Summary Keywords antioxidant system, chronic ethanol exposure, co-supplementation, Lieber-DeCarli liquid diet, oxidative stress, S-adenosyl-L-methionine Citation Nandagopal PB and Manickam V (2026) Restoring redox homeostasis through S-adenosyl-L-methionine and B-vitamins co-supplementation alleviates ethanol induced hepato-pancreatic injury by regulating glutathione biosynthesis in C57BL/6J mice

Aging Cell 18 , e13016 (2019)

Like with most supplements, the research is mixed