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Glutathione depletion is involved in the inhibition of procollagen alpha1(I) mRNA levels caused by TNF-alpha on hepatic stellate cells

ACLY-dependent histone acetylation has also been linked to selective control of key genes involved in glucose usage in adipocytes, including phosphofructokinase (PFK) and glucose transporter 4 (GLUT4) 90

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In this respect, selenosugars seem to be more feasible candidates, since they might exploit glucose- or other transporters ( + is unlikely to be either effectively transported to the brain due to its positive charge and missing capability of effective metabolization in the brain tissue (Suzuki et al., 2006