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More recently, a family of potent and highly selective mechanism-based suicide substrate inhibitors were developed and shown to promote the irreversible inhibition of gut microbiotadependent generation of TMA, suppression of host TMAO levels, and, in parallel, inhibition of platelet hyperresponsiveness and thrombosis potential in animal models (22)

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An early case report [49] described a 70-year-old patient with severe RLS who had a complete remission of symptoms 1 month after smoking cessation