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Additionally, its effects on gut motility and bowel function mean it warrants caution in patients with bowel obstruction or severe gastrointestinal surgery history

Despite the knowledge of T-DXd resistance mechanisms generated through preclinical studies, there are few large population-based studies that have explored resistance to this therapy 4

The Soviet-era research on DSIP in elderly populations specifically targeted this decline

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The possible indirect mechanisms of doxorubicin induced chemo-brain are illustrated in Table 2 and Figure 1