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Nature 497 , 451457 (2013)

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Other cardiometabolic risk exposures (diagnoses of metabolic dysfunction, statin prescriptions) and demographic variables (age, sex, race) were collected

berghei blood stages can grow and develop in vivo in spite of low levels of intracellular GSH Given that -GCS catalyzes the rate-limiting step in GSH de novo biosynthesis, we predicted that disruption of the pbggcs locus would abolish parasite GSH levels