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ACS Pharmacol Transl Sci 7:560569

DAMPs, endogenous molecules including DNA, RNA, and proteins, are produced in response to cellular injury, death or stress

KISIMA-01 trial: Safety, tolerability and immunogenicity of ATP128 with or without ezabenlimab (BI 754091) in patients with stage IV colorectal cancer preliminary results from a Phase 1b study, US

J Supply Chain Manag 44:2239 Dowlati M, Sobhi HR, Esrafili A, FarzadKia M, Yeganeh M (2021) Heavy metals content in edible mushrooms: A systematic review, meta-analysis and health risk assessment

Taken together, it appears that mitochondria have co-opted the ISR as a local iron monitoring system, which can mark and eliminate organelles critically depleted for this essential metal