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This retrograde signaling mechanismmitochondria communicating upstream to the nucleusis what Brnice Benayoun, a faculty member at USC Leonard Davis and co-author on the Reynolds et al

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Rotating sites consistently prevents the tissue trauma that contributes to reactions

These neuronal activation patterns are attenuated or absent in RAMP1/RAMP3 knockout animals, further implicating AMYR and AMYR as the functional receptors mediating these central effects