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It should be noted that Immunocal is included in the Physician's Desk Reference ("Immunocal," 2013)

Inhibition of HDAC by -OHB was correlated with global changes in transcription, including that of the genes encoding oxidative stress resistance factors Forkhead box O3a (FOXO3a) and MT2

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Licochalcone A had the strongest binding affinity ( 7.9 kcal/mol), forming several HBs with Pro219, Ser227, and His233, as well as additional stabilizing interactions such as pi-donor HBs and pi-alkyl interactions