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Furthermore, in ME/CFS, PEM has been associated with defects in the TCA cycle, where a metabolic impairment reduces ATP production and increases lactate accumulation (Nilsson et al., 2020)

These miRNAs mainly include the miR-34 family (including miR-34a, miR-34b, and miR-34c), miR-206, miR-1, and other tumor suppressor miRNAs

Houtgraaf JH, Versmissen J, van der Giessen WJ

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In addition to metabolic abundancy, spatial protein analysis could possibly reveal distinct expression and interaction patterns of BCL-2 proteins that correlate with the specific, zonation-dependent metabolic tasks of hepatocytes [57] or even other bodys nutrient axes