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Thus, TNBS promotes two independent mechanisms of injury, GSH depletion and ROS generation, both being required for the manifestation of mucosal injury as GSH limitation renders intestine susceptible to the TNBS-induced ROS overgeneration

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10.1016/j.pbiomolbio.2004.06.003 133 KumarG.PatnaikR

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Researchers can adjust dosing and duration based on the desired therapeutic effects, target area, severity of condition, and other factors