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The lungs, where the exchange and presence of oxygen is continuous, are particularly vulnerable to reactive oxidative species (ROS), which at excessive levels could overwhelm the availability of antioxidants culminating in oxidative stress

Approximately 33.7% of the population suffers with anxiety related disorders in their life, often comorbid with depression (1)

A mediterranean dietary intervention in female carriers of BRCA mutations: results from an italian prospective randomized controlled trial

Cell Death Dis 10(5):351

GPx4 uses GSH as a reducing substrate and converts it into oxidized form, also referred to as glutathione disulphide (GS-SG) ( NFE2L2 gene) (Habib et al., 2015), the xCT mRNA can be positively regulated by the activation of transcription factor 4 (ATF4) under oxidative stress (Sato et al., 2004), while its negative regulation by p53 results in cysteine deprivation and increased susceptibility to ferroptosis (Jiang et al., 2015)