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Am J Physiol Renal Physiol (2016) 311(1):F14561

In the context of tumor immune microenvironment remodeling, the SSP induces an immunosuppressive phenotype, promotes M2-type macrophage polarization, sustains high PD-L1 expression, impairs the cytotoxic function of CD8 + T cells, and compromises the therapeutic efficacy of CAR-T cells