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AtSufE is an essential activator of plastidic and mitochondrial desulfurases in Arabidopsis

Similarly, long-term treatment with the carnitine inhibitor meldonium can induce adaptive cardioprotective effects by altering energy metabolic pathways [299]

doi:10.1080/14992027.2017.1385862

It usually means either the root cause needs further investigation (which is where functional lab testing becomes valuable) or the protocol needs adjustment