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Tirzepatide is a dual agonist of GIP and GLP-1 receptors, acting in an integrated way across incretin pathways.It increases insulin secretion in a glucose-dependent manner and improves glycaemic regulation (reducing peaks and variability)

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By suppressing gluconeogenesis, hesperidin reduces excessive glucose production in the liver, leading to improved glycemic control

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doi:10.1017/S0029665118001192 [26] Ventura M, Melo M, Carrilho F