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These three basic mechanisms (oxidative stress, chronic inflammation, and endothelial dysfunction) play very important key roles

2.3 Lipid peroxide accumulation Polyunsaturated fatty acids (PUFAs), which are major constituents of organelle membrane phospholipids, are particularly prone to peroxidation during ferroptosis (Han et al., 2025)

Yeh CC, Hou MF, Wu SH, Tsai SM, Lin SK, Hou LA, et al

Ideally some of the cysteine is eventually converted to sulfate which is used as a conjugate for sulphation, a vital phase 2 detoxification pathway that handles many different toxins including excess oestrogen