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The -secretase enzymes are generally believed to reside at the plasma membrane, although some studies have suggested that a pool of -secretase may also exist at the trans -Golgi network (TGN) (Sisodia, 1992

Transport across the BBB may be facilitated by sodium-dependent transport system [76] or converting cysteine to cystine, which is subsequently exchanged with intracellular glutamate via the cystine-glutamate antiporter, and reduced back to cysteine for GSH production [115, 116]

They found that combination therapy could reduce the number of immunosuppressive cells and promote the therapeutic efficacy of antibodies that target CTLA-4 [122] (Table 5)

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