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Both Nrf1 and Nrf2 knockout mice have lower GCLC expression [114,115] and overexpression of Nrf1 and Nrf2 can induce the human GCLC promoter activity [104,116]

Although we did not investigate each of these cell death pathways, we do not deny their potential roles

A static representation of the topology and electrostatic field in the H-site (Warshel, 1998) will have to be complemented with a description of the dynamics of the entire molecule ( Substrate Discrimination in Promiscuous Enzymes GSTs, like many other enzymes involved in detoxication, are promiscuous such that they can act on several different substrates and catalyze many alternative chemical reactions

Emerging role of Ferroptosis in acute kidney injury

311 , F1035F1046 (2016)