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Ipamorelin is a ghrelin receptor agonist (GHS-R1a) that stimulates GH secretion through a mechanistically separate pathway

doi: 10.1016/j.bmcl.2015.07.018 81 LeeY

doi: 10.1160/TH07-01-0039 15 JeonC

It further compromises endothelial barrier integrity by disrupting tight junctions, characterized by reduced levels of ZO-1, occludin, and claudin-5, and by enhancing MMPs through Rho and Ras pathway activation ( Figure 1 )

While day 7 treatment response - measured as lymphoblast count in peripheral blood - is a well-defined, biologically straightforward phenotype with minimal confounding, more complex outcomes such as toxicities or relapse are influenced by numerous biological and environmental factors and require rigorous characterization