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Due to hyperinflation and long-term unfavourable mechanical position, the diaphragm is forced to remain in a state of contraction, which is easy to cause the decline of diaphragm compliance and contraction force, leading to diaphragm fatigue (McKenzie et al., 2009) (Figure 1)

When routinely worn, wearables can deliver useful information about motor activities, which are strongly influenced by fatigue (e.g., gait, balance, social contacts, sports, etc.)

( 10.1002/14651858.CD007411.pub4) [DOI] [PMC free article] [PubMed] [Google Scholar] Steiber A, Kerner J, Hoppel CL.2004

This paper presents the first study of nusinersen in pre-symptomatic infants with SMA-I and SMA-II who were identified through family studies or newborn screening