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CRISPR gene editing, isotope tracing, and gnotobiotic mouse colonization were used to mechanistically interrogate the identified genes

Role of matrix metalloprotease-2 and MMP-9 in experimental lung fibrosis in mice

Abnormal levels of these metabolites have been associated with conditions such as attention deficit hyperactivity disorder (ADHD), depression, and anxiety

Similarly, immunoinflammatory reactions contribute to the development of hyperhomocysteinemia, and in turn, high Homocysteine acts as an immunostimulant and pro-inflammatory molecule, increasing abnormal immune response (Lazzerini et al

Accordingly, altered HSP expression has been implicated in the pathogenesis of multiple metabolic disorders, positioning HSPs as both biomarkers of disease severity and promising, albeit complex, therapeutic targets (Fig