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10.1016/bs.pmbts.2016.05.007 Progress in Molecular Biology and Translational Science 45 WiltonM.Charron-MazenodL.MooreR.LewenzaS

TLR9 is functionally expressed in microglia and astrocytes, which serve as the brains primary immune effector and supporting glial cells, respectively [129]

Palmitate triggers inflammation through TLR4 not by acting as its direct agonist, but by altering cellular metabolism and membrane composition, thereby licensing TLR4-dependent inflammatory responses [36]