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This stability supports its use across biochemical, cellular and preclinical experimental platforms

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However, present approaches of theoretical calculation are usually built upon TBC-based theories, showing huge limitations in accurately describing the electronic structure of aggregates and related noncovalent couplings

In the CNS, they participate in increasing neuronal excitability and promote synaptic plasticity, which are key for learning and memory, through second messenger signaling pathways ( Figure 1 ) according to their pharmacology, sequence of amino acid homology, and signal transduction pathways ( 2+ from intracellular stores in the endoplasmic reticulum, and diacylglycerol activates protein kinase C ( + channels and inhibit voltage-gated Ca 2+ channels ( Figure 1

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