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1991 (landmark Italian trial): A double-blind, placebo-controlled trial involving 130 patients with Alzheimer's disease demonstrated that one year of ALCAR treatment resulted in a slower rate of deterioration compared to placebo across 13 of 14 outcome measures, including significant improvements in the Blessed Dementia Scale, logical intelligence, verbal critical abilities, long-term verbal memory, and selective attention [5][17]

4.3.3 Clinical outcomes and trials Liver transplantation is seeing improvement in early allograft function partly thanks to these targeted interventions

The biology is unusual

Consequently, mitochondrial dysfunction has been identified as a central contributor to the onset and progression of various cardiovascular diseases, including HF, myocardial ischemia/reperfusion (I/R) injury, and atherosclerosis