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Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) is a key regulator of mitochondrial biogenesis and modulates OXPHOS and FAO by inducing the expression of nuclear respiration factor 1 (Nrf-1) and mitochondrial transcription factor A (Tfam) ( Furthermore, another cycle has been elucidated recently: the gluconeogenesisglycogenolysis cycle, which activated by cytosolic phosphoenolpyruvate carboxykinase (PckCK1, the enzyme converting oxaloacetate (OAA) to phosphoenolpyruvate (PEP) and is highly expressed in Tcm) to fuel flux into the PPP, leading to enhanced generation of NADPH, thus protecting against ROS to support the long-term survival of CD8+Tm cells ( 2.3.2 Tem Tem cells are commonly found in nonlymphoid tissues and continuously circulate through the blood, expressing CD45RO, CD122, CD95, KLRG1, LFA-1, IL-18R, and chemokine receptors but are negative for CD62L, CCR7, and CD31

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