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[6] measured cerebral perfusion after providing a group of older adults (~75 years) a high nitrate diet (~12 mmol) including beetroot juice, or a nitrate depleted diet (~0.09 mmol) for 24 h

This effect seems to be independent of mu opioid peptide receptors (MOP), as it was not reversed by the MOP antagonist naltrexone, nor mimicked by the MOP agonist methadone [65]

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Pagano PJ, Clark JK, Cifuentes-Pagano ME, Clark SM, Callis GM, Quinn MT

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