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hEPO mRNAs were synthesized in vitro using T7RNA polymerase-mediated DNA-dependent RNA transcription, where UTP was substituted with 100% N^methylpseudouracil (NIMPU), using a linearized template for each UTR combination

The theory holds that high lactic acid buildup makes IGF-1 receptors more receptive, so injecting into muscles about to be trained maximizes local effects

Statements Author contributions NG, DW, and PA drafted the manuscript and BP, NS, KS, DW, and PA helped in literature search and edited the manuscript

What's missing, and this matters: - As of 2026, no controlled trial has shown that ipamorelin actually improves body composition, sleep, or recovery over meaningful timeframes

Most users find eating large meals physically uncomfortable and naturally gravitate toward smaller, more frequent meals