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10.1016/j.neuroscience.2016.01.026 Neuroscience 12 BasslerR

For many people, suboptimal B12 levels are a significant and correctable contributing factor

Even metformin (metf), the US Food and Drug Administrations (FDA) recommended front-line medicine for DM (44), is devoid of contraindications (45, 46), yet it fails to exert its therapeutic effect due to patient noncompliance (47)

Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate