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Increased 12/15-lipoxygenase leads to widespread brain injury following global cerebral ischemia

Kekec Y, Paydas S, Tuli A, Zorludemir S, Sakman G, Seydaoglu G

J., Hoeksma, M., Reijngoud, D.-J

[22] Diphenhydramine acts as a reversible, competitive antagonist-and more precisely, an inverse agonist-at the histamine H receptor, thereby stabilizing the inactive receptor conformation and preventing histamine-mediated vasodilation, increased capillary permeability, and sensory nerve activation