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In recent years, much progress has been made in fabricating functionalized nerve guidance conduits loaded with different types of bioactive noncellular or cellular components, particularly the combination with multipotent mesenchymal stem cells (MSCs) of different tissue origins, including dental tissues [12, 13]

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Similarly, compounds from the spiro-oxindole dihydroquinazolinone series identified in the screening, e.g., 42 are weak inhibitors and besides that not stable in in vitro assays

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Their mechanisms range from angiogenesis and cytoprotection to tight-junction regulation and immune modulation, and the maturity of the evidence varies considerably across the group