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(2019) 6:e562

( We believe this clarification helps ensure clarity on CMS' policy in applying rebate reductions, which is intended to provide appropriate financial relief to a manufacturer experiencing a potential shortage while limiting opportunities for manufacturers to plan future price increases to coincide with the application of the reduction

Metabolic reprogramming induced by glutamine metabolism Unsurprisingly, glutamine metabolism plays a critical role in tumor progression since it not only supports mitochondrial oxidative phosphorylation but also supplies metabolic intermediates for the TCA cycle, glutathione synthesis, and NEAA synthesis and simultaneously produces NADPH 157,158,159