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Upon activation through TCR signaling, these naive T cells switch to a glycolytic metabolic profile to support their differentiation into effector T cells

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Specifically, under energy stress, intestinal Bifidobacterium pseudolongum -upregulated Cr production activates the AMP-activated protein kinase (AMPK) pathway, suppressing ionizing radiation-induced PUFA synthesis and thereby counteracting ionizing radiation-associated ferroptosis progression (He Y

By maintaining an optimum level of NAD+, cells can respond to the WS phenotype, which provides a basis for NAD+ to simultaneously act in the maintenance of multiple organ functions, thereby benefiting the working environment of the heart

43 Notably, single MCT4 inhibition can reverse lactate-driven immunosuppression and increase the efficacy of immune checkpoint blockade (ICB) therapy