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The expression of arginases including ARG1 and ARG2 has been reported to be increased in cancers, such as gastric cancer, breast cancer, prostate cancer, colorectal cancer, and AML (Leu and Wang, 1992

4.3 NO-releasing agents in overcoming tumor hypoxia Tumor hypoxia, a hallmark of solid malignancies such as CRC, drives therapeutic resistance, immunosuppression, and metastasis