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[43] Embryotoxic and teratogenic effects (syndactylia and oligodactylia) have been demonstrated in animals receiving oral ketoconazole doses at 10-times the maximum recommended human dose

An anatomical T1 MPRAGE image (TE/TR = 3.4/7.3 ms) was acquired for each subject (1 mm isotropic resolution, 256 256 180 matrix, flip angle 8) to aid placement of the VOIs and for co-registration

These results suggested that chronic hypoxia resulted in an increase in p--syn phosphorylation and abnormal aggregation