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Similarly, in the ARIC study, high intake of cruciferous vegetables was associated with lower risks of kidney failure, with stronger effects in those homozygous for the null allele ( GSTM1(0/0) ), compared to those carrying one or two copies of the active allele [130]

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225 In addition, a modest dose of WA was shown to induce ferroptosis and increase the LIP by directly targeting KEAP1, mediating the NRF2-mediated upregulation of HO-1