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Research Use Limitation Used solely for in vitro experiments Not permitted for clinical trials involving humans Not permitted for human or veterinary administration Not permitted for investigational human use Independently analysed by Liquilabs s.r.o

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Therefore, the disturbance of oligodendrocyte mitochondria, the resultant energy shortage, ROS accumulation, and disturbance of lipid and protein synthesis, is discussed as a mode of action of cuprizone toxicity [20, 107, 108]