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These new policies include a one-time burden of $1,461.80 per hospital, and a total national cost of $10,840,708.80 ($1,461.80 7,416 hospitals)

While these results seem at odds with the common use of NAC as ROS scavenger, more recent literature shows that NAC also can enhance ROS generation under conditions, where cells express a certain pattern of enzymes that regulate ROS production (53), are co-treated with certain ROS generators (54), or suffer from mitochondrial stress (55)

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