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This impaired activation is hypothesized to stem from defects in the actin cytoskeleton, which is often disorganized in FXN -deficient cells, thereby hindering the efficient nuclear translocation of Nrf2

The dihydroxy- and hydroxy, methoxy-cinnamic acids possessed higher antioxidant activity measured in DPHH, ABTS, CUPRAC and FRAP assays compared to monohydroxycinnamic acids

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Kane AJ, Brennan CM, Xu AE, et al

A number of malignancies impact amino acid metabolism and particularly their transport system, which indicates that targeting these pathways could be a potential approach for treating certain types of cancers (12)