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For tissues, mice from different groups were euthanized by inhalation anesthesia

Left ventricular tissue was harvested from explanted human failing hearts and donor non-failing human hearts via HELP (Human Explanted Heart Program) at the Mazankowski Alberta Heart Institute and the HOPE (Human Organ Procurement and Exchange) program at the University of Alberta Hospital

BT analyzed data, performed the literature search and the systematic review, drafted the figures, and co-wrote the manuscript

Evaluation of novel chalcone oximes as inhibitors of tyrosinase and melanin formation in B16 cells

31 showed that -synuclein accumulation could be reduced in LRRK2 G2019S hMLO through treatment with a LRRK2 kinase activity inhibitor (GSK2578215A), but also by knocking down the expression of TXNIP, which their study had identified as a central mediator of G2019S pathology