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yet, citrate is made in bulk amounts using either (i) carbons from glutamine by the process of reductive carboxylation of -ketoglutarate 98,282,283 (Fig

Amino acid metabolism has extremely extensive effects in cancer cells, including, but not limited to, (1) establishing amino acid pools as building blocks, especially the production of non-essential amino acids for protein biosynthesis, conversion to glucose, lipids, and precursors of nitrogen-containing metabolites, such as purines and pyrimidines for nucleic acid synthesis