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Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

Sochman, J., N-Acetylcysteine Somewhere Between Scylla and Charybdis

P., Cummins, I., Cole, D

Glutaminolysis as a target for cancer therapy

for example, it protects membranes by maintaining the reduced state of both -tocopherol and zeaxanthin, it prevents the oxidative denaturation of proteins under stress conditions by protecting their thiol groups, and it serves as a substrate for both glutathione peroxidase and glutathione S -transferase