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High-dose oral supplementation may be another treatment option, because consuming 1,000 g (1 mg) per day of vitamin B 12 orally should result in the absorption of about 10 g/day (1% of dose) by passive diffusion

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Finally, although this study focused on a single induction protocol, variations in differentiation methods across research groups may affect maturation timelines, limiting the direct applicability of findings to alternate protocols