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In one study, administration of lipoic acid improved survival in a mouse model of ALS (Andreassen 2001b)

doi: 10.1088/1742-6596/2063/1/012003 177 CismesiaAPNichollsGRPolferNC

Although migrasomes have been detected in the infarcted brain parenchyma of stroke patients and described as a new mechanism in the pathophysiology of acute stroke, further research regarding these structures is needed ( Mitochondrial Therapeutics for Parkinsons Disease The mechanisms of PD pathology related to mitochondrial dysfunction have motivated the development of novel anti-PD therapies

Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]