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Notably, systemic inflammatory disorders are associated with the progression of PD

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Therefore, these findings suggest that our nanoparticles penetrated the corneal barrier by compromising the tight junctions of the corneal epithelium, thereby promoting their antioxidant performance in the anterior capsules of the mouse lens

This lipid overload renders hepatocytes vulnerable to oxidative injury through enhanced generation of reactive oxygen species (ROS), mitochondrial respiratory dysfunction, and endoplasmic reticulum stress

EGFR pathway ROS promote ligand-independent initiation of EGFR in several ways, involving EGFR phosphorylation at the Tyr845 residue, 280 and/or inhibition of EGFR inhibitory PTPs (at Cys124 and Cys71) and/or Cys797 oxidation of EGFR