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The weight gain in HFD-fed rats is likely attributed to the consumption of diets enriched in saturated fats, such as lard, resulting in a significant increase in dietary energy intake

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74 Recent findings suggest that the demethyltransferases fat mass and obesity-associated protein in macrophages facilitate the transition from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype, modulating inflammation and glycolysis through N6-methyladenosine modification of the neuronal PAS domain protein 2

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