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10.1016/j.mam.2016.08.001 57

Looking ahead, monitoring integrin drug concentrations, genetic risk scores, and intestinal immune phenotyping will enable integrin inhibitors to play a greater role in the personalized and precise treatment of moderate-to-severe UC/CD [314, 315]

Contains phospholipids derived from soy lecithin

The simultaneous inhibition of autophagy and JAK2 led to greater decreases in cancer stem cell populations and markers of drug resistance, highlighting the crucial relationship between autophagy and JAK/STAT signaling in maintaining chemoresistance and the characteristics of cancer stem cells [278]

198,199 Indeed, LKB1-mutated patients respond better than wild-type patients to therapies with platinum-based anticancer drugs, 200 which are potent inducers of ROS