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The renoprotective effects of diosmin were found attributable to its suppressing activity on lipid peroxidation, potentiating activity on antioxidant enzymes, and its modulatory effect on the expressions of Bax and p53 proteins [127]

Black cumin extract or its active components were shown to reduce NO level by modulating the activity of nitrite reductase [154,164,166], indicating that this natural product can protect against NO-mediated hepatic complications

Advances in metabolite processing methods and metabolite identification tools, such as Bio-Transformer, are expected to further expand the number of annotated metabolites, enhancing the comprehensive coverage enabled by of metabolic databases (Djoumbou-Feunang et al., 2019

These mechanisms are likely generic in eukaryotes, because very similar pat- terns of recruitment of GSH into the nucleus have been observed in plant and animal cells (Markovic et al., 2007

The psychopharmacology algorithm project at the Harvard South Shore Program: an algorithm for adults with obsessive-compulsive disorder